Human Syndecan-4/SDC4 ELISA Kit PicoKine® | Boster EK1356 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Syndecan-4/SDC4 ELISA Kit PicoKine®

catalog :

EK1356

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1356

Product Name :

Human Syndecan-4/SDC4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Syndecan-4/SDC4 ELISA Kit PicoKine® (96 Tests). Quantitate Human SDC4 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

SDC4

Uniprot ID :

P31431

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E19-E145

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Syndecan-4

Synonyms :

Syndecan-4;SYND4;Amphiglycan;Ryudocan core protein;SDC4;

Protein Name :

Syndecan-4

Molecular Weight :

21642 MW

Protein Function :

Cell surface proteoglycan that bears heparan sulfate.

Subcellular Localization :

Isoform 1: Membrane; Single-pass type I membrane protein. Secreted. Shedding of the ectodomain produces a soluble form.

Tissue Specificity :

Expressed in epithelial and fibroblastic cells.

Background :

Syndecan-4 (SDC4) is a protein that in humans is encoded by the SDC4 gene. The protein is found as a homodimer and is a member of the syndecan proteoglycan family. It is mapped to 20q13.12. Syndecan-4 is one of the four vertebrate syndecans and has a molecular weight of ~20 kDa. It is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. Syndecan-4 also regulates the actin cytoskeleton, cell adhesion, and cell migration. In addition, Syndecan-4 can activate protein kinase C (PKC). The variable domain of syndecan-4 could be a site of self-association. What’s more, Syndecan-4 also binds to phosphatidylinositol (4,5)-bisphosphate (PIP2) through the variable domain and increases PKC activity ten-fold.

Research Category :

Cell Adhesion Proteins, Cytoskeleton / Ecm, Ecm Proteins, Neurogenesis, Neurology Process, Neuroscience, Plasma Membrane, Signal Transduction, Subcellular Markers, Tags & Cell Markers