Human JAM-A / F11R / Junctional Adhesion Molecule 1 ELISA Kit PicoKine®

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human JAM-A / F11R / Junctional Adhesion Molecule 1 ELISA Kit PicoKine®

catalog :

EK1349

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Ong K, Leung R, Babinska A, Salifu M, Ehrlich Y, Kornecki E, et al. Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. Am J Hypertens. 2009;22:500-5 pubmed publisher

image

image 1 :

Human JAM-A PicoKine ELISA Kit standard curve

product information

SKU :

EK1349

Product Name :

Human JAM-A / F11R / Junctional Adhesion Molecule 1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human JAM-A / F11R / Junctional Adhesion Molecule 1 ELISA Kit PicoKine® (96 Tests). Quantitate Human F11R in cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

F11R

Uniprot ID :

Q9Y624

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S28-V238

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

46.9 pg/ml - 3,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Junctional adhesion molecule A

Synonyms :

Junctional adhesion molecule A;JAM-A;Junctional adhesion molecule 1;JAM-1;Platelet F11 receptor;Platelet adhesion molecule 1;PAM-1;CD321;F11R;JAM1, JCAM;UNQ264/PRO301;

Protein Name :

Junctional adhesion molecule A

Molecular Weight :

32583 MW

Protein Function :

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.

Subcellular Localization :

Cell junction, tight junction . Cell membrane ; Single-pass type I membrane protein . Localized at tight junctions of both epithelial and endothelial cells.

Sequence Similarities :

Belongs to the immunoglobulin superfamily.

Background :

Junctional adhesion molecule A (JAM-A) is a protein that in humans is encoded by the F11R gene. It is mapped to 1q23.3. This gene is an immunoglobulin-like molecule that colocalizes with tight junctions in endothelium and epithelium and is also found on blood leukocytes and platelets. JAM-A plays an important role in the regulation of tight junction assembly in epithelia. In addition, it can act as a receptor for reovirus, a ligand for the integrin LFA1, involved in leukocyte transmigration, and a platelet receptor. JAM-A has a nonredundant role in controlling DC motility, trafficking to lymph nodes, and activation of specific immunity.

Research Category :

Atherosclerosis, Cardiovascular, Cell Adhesion, Cytoskeleton / Ecm, Platelets, Signal Transduction, Tight Junctions, Vascular Inflammation

more info or order :

Boster product webpage