Rat Neuropilin-2 ELISA Kit PicoKine® | Boster EK1345 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat Neuropilin-2 ELISA Kit PicoKine®

catalog :

EK1345

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1345

Product Name :

Rat Neuropilin-2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat Neuropilin-2 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Nrp2 in cell culture supernatants and cell lysates. Sensitivity: 10pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

NRP2

Uniprot ID :

O35276

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q23-D857

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and cell lysate

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Neuropilin-2

Synonyms :

Neuropilin-2;Vascular endothelial cell growth factor 165 receptor 2;Nrp2;

Protein Name :

Neuropilin-2

Molecular Weight :

103897 MW

Protein Function :

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Found in certain neuronal populations of the CNS and in other non-neuronal tissues including mesenchymal tissue lining in the ribs.

Sequence Similarities :

Belongs to the neuropilin family.

Background :

NRP2 (Neuropilin-2), also called Npn2 or VEGF165R2, encodes a member of the neuropilin family of receptor proteins. The soluble NRP2 was secreted as a 62.5-kD protein following transfection in Chinese hamster ovary cells. The NRP2 gene is mapped to 2q33.3. The NRP2 gene contains 17 exons and spans about 112 kb. This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Mice with null mutations in genes encoding Sema3F, and its holoreceptor components Npn2 and plexin A3 (PLEXA3), exhibit increased dentate gyrus granule cell and cortical layer V pyramidal neuron spine number and size, and also aberrant spine distribution. Moreover, Sema3F promotes loss of spines and excitatory synapses in dissociated neurons in vitro, and in NRP2-null brain slices cortical layer V and dentate gyrus granule cells exhibit increased miniature excitatory postsynaptic current frequency. These disparate effects of secreted semaphorins are reflected in the restricted dendritic localization of NRP2 to apical dendrites and of Npn1 to all dendrites of cortical pyramidal neurons.

Research Category :

Axonal Guidance Proteins, Cell Type Marker, Growth And Development, Neurology Process, Neuron Marker, Neuroscience