Mouse Neuropilin-1 ELISA Kit PicoKine® | Boster EK1342 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse Neuropilin-1 ELISA Kit PicoKine®

catalog :

EK1342

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Lu Y, Xiang H, Liu P, Tong R, Watts R, Koch A, et al. Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration. MAbs. 2009;1:364-9 pubmed

image

image 1 :

Mouse Neuropilin-1 PicoKine ELISA Kit standard curve

product information

SKU :

EK1342

Product Name :

Mouse Neuropilin-1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Mouse Neuropilin-1 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Nrp1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 20pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

NRP1

Uniprot ID :

P97333

Immunogen :

Expression system for standard: NS0; Immunogen sequence: F22-P856

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

780 pg/ml - 50000 pg/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Neuropilin-1

Synonyms :

Neuropilin-1;A5 protein;CD304;Nrp1;Nrp;

Protein Name :

Neuropilin-1

Molecular Weight :

103000 MW

Protein Function :

Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity).

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Nervous system

Sequence Similarities :

Belongs to the neuropilin family.

Background :

NRP1 (Neuropilin 1) also known as NP1, NRP, BDCA4 or VEGF165R, is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF) and semaphorin family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion. By somatic cell hybrid analysis, the NRP1 gene was mapped to chromosome 10. NRP1 bounds PGF1 with lower affinity. NRP1-mediated interactions are a necessary element in the initiation of the primary immune response and offer another example, like that of agrin, of a molecule shared by neurologic and immunologic synapses. After T-cell contact with DC, T-cell NRP1 colocalized with CD3 in the immunologic synapse and, sometimes, also at the opposite pole of the T cell. Soluble NRP1 interacts in a homophilic fashion with NRP1 on both DC and T cells, and this binding can be inhibited by blocking antibodies to NRP1. Furthermore, selective NRP1 inhibition in this model suppressed neovascular formation substantially.

Research Category :

Adaptive Immunity, Angiogenesis, Axonal Guidance Proteins, Cardiovascular, Growth And Development, Growth Factors, Immunology, Neurology Process, Neuroscience

more info or order :

Boster product webpage