Human ADAMTS1 ELISA Kit PicoKine® | Boster EK1340 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ADAMTS1 ELISA Kit PicoKine®

catalog :

EK1340

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1340

Product Name :

Human ADAMTS1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human ADAMTS1 ELISA Kit PicoKine® (96 Tests). Quantitate Human ADAMTS1 in cell culture supernatants, serum and plasma (heparin). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ADAMTS1

Uniprot ID :

Q9UHI8

Immunogen :

Expression system for standard: NS0; Immunogen sequence: F253-A734

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.8 pg/ml - 6,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

A disintegrin and metalloproteinase with thrombospondin motifs 1

Synonyms :

A disintegrin and metalloproteinase with thrombospondin motifs 1;ADAM-TS 1;ADAM-TS1;ADAMTS-1;3.4.24.-;METH-1;ADAMTS1;KIAA1346, METH1;

Protein Name :

A disintegrin and metalloproteinase with thrombospondin motifs 1

Molecular Weight :

105358 MW

Protein Function :

Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.

Subcellular Localization :

Secreted, extracellular space, extracellular matrix .

Sequence Similarities :

Contains 1 disintegrin domain.

Background :

ADAMTS1 (A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 1), also known as METH1, is an enzyme that in humans is encoded by the ADAMTS1 gene. ADAMTS is a family of proteins believed to be anchored to the extracellular matrix (ECM) through interactions with aggregan or other matrix components by one or more thrombospondin type 1 motifs. ADAMTS1 gene is mapped to 21q21.2 based on sequence similarity between the ADAMTS1 sequence and a chromosome 21q21.2 clone. It has been found that ADAMTS1 can disrupt angiogenesis in vivo and in vitro more efficiently than ADAMTS8, THBS1, or endostatin. What’s more, ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, THBS1, or endostatin.

Research Category :

Tags & Cell Markers, Tumor Associated