Mouse TIMP-4 ELISA Kit PicoKine® | Boster EK1335 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse TIMP-4 ELISA Kit PicoKine®

catalog :

EK1335

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1335

Product Name :

Mouse TIMP-4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse TIMP-4 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Timp4 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

TIMP4

Uniprot ID :

Q9JHB3

Immunogen :

Expression system for standard: NS0; Immunogen sequence: C30-P224

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

78 pg/ml - 5,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Metalloproteinase inhibitor 4

Synonyms :

Metalloproteinase inhibitor 4;Tissue inhibitor of metalloproteinases 4;TIMP-4;Timp4;

Protein Name :

Metalloproteinase inhibitor 4

Molecular Weight :

25774 MW

Protein Function :

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed in brain, heart, ovary and skeletal muscle.

Sequence Similarities :

Belongs to the protease inhibitor I35 (TIMP) family.

Background :

Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene. This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. TIMP4 gene is mapped to chromosome 3p25. TIMP4 gene contains 5 exons that span 6 kb of genomic DNA. The gene is expressed as a 1.4-kb transcript abundant in heart and present at low levels in several other tissues. Expressed TIMP4 inhibits MMPs in vitro. What’s more, TIMP-4 binds both progelatinase A and the C domain in a similar manner to that of TIMP-2.

Research Category :

Angiogenesis, Cancer, Cardiovascular, Cell Biology, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Protease Inhibitors, Proteolysis / Ubiquitin