Mouse MADCAM-1 ELISA Kit PicoKine® | Boster EK1332 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse MADCAM-1 ELISA Kit PicoKine®

catalog :

EK1332

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1332

Product Name :

Mouse MADCAM-1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse MADCAM-1 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Madcam1 in cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

MADCAM1

Uniprot ID :

Q61826

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q22-T365

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

125 pg/ml - 8,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Mucosal addressin cell adhesion molecule 1

Synonyms :

Mucosal addressin cell adhesion molecule 1;MAdCAM-1;mMAdCAM-1;Madcam1;

Protein Name :

Mucosal addressin cell adhesion molecule 1

Molecular Weight :

43652 MW

Protein Function :

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Highly expressed on high endothelial venules (HEV) of organized intestinal lymphoid tissues like the Peyer patches and mesenteric lymph nodes, and in the lamina propria of the intestine. Some expression found in the spleen, and low levels of expression in the peripheral lymph nodes and the lactating mammary gland. No expression was detected in the liver, kidneys, lungs or in normal brain. Expressed as well in brain endothelioma cells, and mucosal tissues which are in a chronic state of inflammation, such as inflammed pancreas.

Background :

MADCAM1 (Mucosal Vascular Addressin Cell Adhesion Molecule 1), also known as MACAM1, is a protein that is encoded by the MADCAM1 gene. By PCR-based analysis of somatic cell hybrids, Leung et al (1997) mapped the MACAM1 gene to chromosome 19. The protein encoded by this gene is an endothelil cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4/beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.

Research Category :

Angiogenesis, Cardiovascular, Cell Adhesion, Cell Adhesion Proteins, Cytoskeleton / Ecm, Immunology, Innate Immunity, Integrins, Macrophage / Inflamm., Neuroscience, Receptors, Signal Transduction