Human DKK-3 ELISA Kit PicoKine® | Boster EK1323 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human DKK-3 ELISA Kit PicoKine®

catalog :

EK1323

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Jiang T, Huang L, Wang S, Zhang S. Clinical significance of serum Dkk-3 in patients with gynecological cancer. J Obstet Gynaecol Res. 2010;36:769-73 pubmed publisher

image

image 1 :

Human DKK-3 PicoKine ELISA Kit standard curve

product information

SKU :

EK1323

Product Name :

Human DKK-3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human DKK-3 ELISA Kit PicoKine® (96 Tests). Quantitate Human DKK3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

DKK3

Uniprot ID :

Q9UBP4

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A22-I350

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Dickkopf-related protein 3

Synonyms :

Dickkopf-related protein 3;Dickkopf-3;Dkk-3;hDkk-3;DKK3;REIC;UNQ258/PRO295;

Protein Name :

Dickkopf-related protein 3

Molecular Weight :

38390 MW

Protein Function :

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Subcellular Localization :

Secreted.

Tissue Specificity :

Highest expression in heart, brain, and spinal cord.

Background :

Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene. This gene encodes a protein that is a member of the dickkopf family. It is mapped to 11p15.3. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Members of the Dkk-related family display unique patterns of mRNA expression in human and mouse tissues, and are secreted when expressed in 293T cells. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Research Category :

Adapters, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Transmembrane

more info or order :

Boster product webpage