Human SLAM/CD150 ELISA Kit PicoKine® | Boster EK1321 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human SLAM/CD150 ELISA Kit PicoKine®

catalog :

EK1321

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1321

Product Name :

Human SLAM/CD150 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human SLAM/CD150 ELISA Kit PicoKine® (96 Tests). Quantitate Human SLAMF1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

SLAMF1

Uniprot ID :

Q13291

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A21-K236

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Signaling lymphocytic activation molecule

Synonyms :

Signaling lymphocytic activation molecule;CDw150;IPO-3;CD150;SLAMF1;SLAM;

Protein Name :

Signaling lymphocytic activation molecule

Molecular Weight :

37231 MW

Protein Function :

High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

Subcellular Localization :

Cell membrane; Single-pass type I membrane protein. Present on the surface of B-cells and T-cells.

Tissue Specificity :

Constitutively expressed on peripheral blood memory T-cells, T-cell clones, immature thymocytes and a proportion of B-cells, and is rapidly induced on naive T-cells after activation.

Sequence Similarities :

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Background :

Signaling lymphocytic activation molecule is a protein that in humans is encoded by the SLAMF1 gene. It belongs to the immunoglobulin gene superfamily. This gene is mapped to 1q23.3. It has found that SLAM is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes and a proportion of B cells, and is rapidly induced on naive T cells after activation. In MV-resistant cell lines, infection with clinical MV and expression of SLAM, but not CD46, caused cytopathic effects (CPE). The expression of SLAM on activated B and T lymphocytes correlates with the pathology of MV infection in humans and monkeys, in which lymphoid organs are the chief sites of MV replication and the binding of MV to SLAM may impair the signaling functions of SLAM in lymphocyte activation and inhibit Th0/Th1 cytokine production, thereby promoting Th2 cytokine production. It has reported that antibody-mediated ligation of SLAM on thymocytes triggered a protein tyrosine phosphorylation signal in T cells in a SAP-dependent manner. This signal also involved SHIP, the adaptor molecules DOK2, DOK1, and SHC and RASGAP.

Research Category :

Cell Type Markers, Hematopoietic Progenitors, Host Virus Interaction, Immunology, Interspecies Interaction, Microbiology, Stem Cells, Surface Molecules