Human Fc gamma RIIB/C (CD32b/c)(FCGR2B/C) ELISA Kit PicoKine®

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Fc gamma RIIB/C (CD32b/c)(FCGR2B/C) ELISA Kit PicoKine®

catalog :

EK1312

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1312

Product Name :

Human Fc gamma RIIB/C (CD32b/c)(FCGR2B/C) ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Fc gamma RIIB/C (CD32b/c) (FCGR2B/C) ELISA Kit PicoKine® (96 Tests). Quantitate Human FCGR2B/C in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

FCGR2B

Uniprot ID :

P31994/P31995

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A46-P217

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

46.9 pg/ml - 3,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Fc fragment of IgG receptor IIb/c

Synonyms :

Low affinity immunoglobulin gamma Fc region receptor II-c;IgG Fc receptor II-c;CDw32;Fc-gamma RII-c;Fc-gamma-RIIc;FcRII-c;CD32;FCGR2C;CD32, FCG2, IGFR2;FCGR2B

Protein Name :

Low affinity immunoglobulin gamma Fc region receptor II-b/c

Molecular Weight :

35578 MW

Protein Function :

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.

Subcellular Localization :

Isoform IIC4: Cytoplasm .

Tissue Specificity :

Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.

Sequence Similarities :

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Background :

CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling. It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loops essentially lowers the production of IgG produced by B cells when there is a surplus in the body.

Research Category :

Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Myeloid, Receptors, Stem Cells, T Lymphocytic Lineage