Human SPARCL1/SPARC-like protein 1 ELISA Kit PicoKine®

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human SPARCL1/SPARC-like protein 1 ELISA Kit PicoKine®

catalog :

EK1309

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1309

Product Name :

Human SPARCL1/SPARC-like protein 1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human SPARCL1/Sparc Like 1 ELISA Kit PicoKine® (96 Tests). Quantitate Human SPARCL1 in cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

SPARCL1

Uniprot ID :

Q14515

Immunogen :

Expression system for standard: NS0; Immunogen sequence: I17-F664

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

46.9 pg/ml - 3,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

SPARC-like protein 1

Synonyms :

SPARC-like protein 1;High endothelial venule protein;Hevin;MAST 9;SPARCL1;

Protein Name :

SPARC-like protein 1

Molecular Weight :

75208 MW

Subcellular Localization :

Secreted, extracellular space, extracellular matrix .

Tissue Specificity :

Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.

Sequence Similarities :

Belongs to the SPARC family.

Background :

SPARCL1 (SPARC-Like Protein 1), also known as HEVIN, is a protein that in humans is encoded by the SPARCL1 gene. The cells in high endothelial venules (HEVs) in lymphoid tissues have a plump, almost cuboidal, appearance and support high levels of lymphocyte extravasation from blood, possibly due to the presence of desmosome-like junctions rather than tight junctions in the HEVs. In chronic inflammation, the activated endothelium of nonlymphoid tissues acquires an HEV-like morphology and function. SPARCL1 is highly expressed in HEV and is thought to contribute to the induction or maintenance of features of the HEV endothelium that facilitate lymphocyte migration.

Research Category :

Cancer, Oncoproteins/Suppressors, Tumor Biomarkers, Tumor Suppressors