Mouse TNFSF18/GITRL ELISA Kit PicoKine® | Boster EK1308 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse TNFSF18/GITRL ELISA Kit PicoKine®

catalog :

EK1308

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1308

Product Name :

Mouse TNFSF18/GITRL ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse TNFSF18/GITRL ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Tnfsf18 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

TNFSF18

Uniprot ID :

Q7TS55

Immunogen :

Expression system for standard: NS0; Immunogen sequence: T47-S173

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor ligand superfamily member 18

Synonyms :

Tumor necrosis factor ligand superfamily member 18;GITR ligand;GITRL;Glucocorticoid-induced TNF-related ligand;Tnfsf18;Gitrl;

Protein Name :

Tumor necrosis factor ligand superfamily member 18

Molecular Weight :

19732 MW

Protein Function :

Cytokine that binds to TNFRSF18/AITR/GITR (PubMed:14521928, PubMed:14647196). Regulates T-cell responses (PubMed:14647196). Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation (PubMed:14608036, PubMed:15128759). Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B (PubMed:14521928, PubMed:14647196, PubMed:18178614). Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (By similarity). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (PubMed:24107315).

Subcellular Localization :

Cell membrane ; Single-pass type II membrane protein .

Tissue Specificity :

Detected in immature and mature dendritic cells and in macrophages (at protein level). Detected in spleen, lung, heart, thymus, monocytes, macrophages, B-cells and dendritic cells.

Background :

Tumor necrosis factor ligand superfamily member 18, also known as AITRL or GITRL, is a protein that in humans is encoded by the TNFSF18 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is mapped to 1q25.1. TNFSF18 is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. TNFSF18-dependent modulation of tryptophan catabolism may represent an important mechanism of action of glucocorticoids, both physiologically and therapeutically.

Research Category :

Cancer, Cardiovascular, Cell Type Markers, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Tags & Cell Markers, Tnf Superfamily, Vasculature