Human Cathepsin E ELISA Kit PicoKine® | Boster EK1306 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Cathepsin E ELISA Kit PicoKine®

catalog :

EK1306

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Fisher O, Levert Mignon A, Lord S, Botelho N, Freeman A, Thomas M, et al. High Expression of Cathepsin E in Tissues but Not Blood of Patients with Barrett's Esophagus and Adenocarcinoma. Ann Surg Oncol. 2015;22:2431-8 pubmed publisher

image

image 1 :

Human Cathepsin E PicoKine ELISA Kit standard curve

product information

SKU :

EK1306

Product Name :

Human Cathepsin E ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human Cathepsin E ELISA Kit PicoKine® (96 Tests). Quantitate Human CTSE in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CTSE

Uniprot ID :

P14091

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q18-P396

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cathepsin E

Synonyms :

Cathepsin E;3.4.23.34;Cathepsin E form I;Cathepsin E form II;CTSE;

Protein Name :

Cathepsin E

Molecular Weight :

43312 MW

Protein Function :

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.

Subcellular Localization :

Endosome . The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.

Tissue Specificity :

Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B- lymphocytes.

Background :

Cathepsin E is a protein that in humans is encoded by the CTSE gene. It is mapped to 1q32.1. The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. Cathepsin E is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen, and it also has an important role in immune responses.

Research Category :

Adaptive Immunity, Immunology, Innate Immunity, Macrophage / Inflamm.

more info or order :

Boster product webpage