Rat CCL7/MCP-3 ELISA Kit PicoKine® | Boster EK1300 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat CCL7/MCP-3 ELISA Kit PicoKine®

catalog :

EK1300

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1300

Product Name :

Rat CCL7/MCP-3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat CCL7/MCP-3 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Ccl7 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

Ccl7

Uniprot ID :

Q9QXY8

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: Q24-P97

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-C motif chemokine ligand 7

Synonyms :

C-C motif chemokine 7; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; Small-inducible cytokine A7; Ccl7; Mcp3, Scya7;

Protein Function :

Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity (By similarity).

Subcellular Localization :

Secreted.

Background :

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). It belongs to the C-C chemokine family. By fluorescence in situ hybridization, mapped the MCP3 gene to chromosome 17q11.2-q12. MCP3 was identified as a physiologic substrate of gelatinase A. Cleaved MCP3 binds to CC-chemokine receptors-1, -2, and -3, but no longer induces calcium fluxes or promotes chemotaxis, and instead acts as a general chemokine antagonist that dampens inflammation, suggested that matrix metalloproteinases are both effectors and regulators of the inflammatory response.

Research Category :

Chemokines, Immunology, Innate Immunity, Macrophage / Inflamm.