Rat CD36/SR-B3/GP4 ELISA Kit PicoKine® | Boster EK1299 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat CD36/SR-B3/GP4 ELISA Kit PicoKine®

catalog :

EK1299

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1299

Product Name :

Rat CD36/SR-B3/GP4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat CD36/SR-B3 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Cd36 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

CD36

Uniprot ID :

Q07969

Immunogen :

Expression system for standard: CHO; Immunogen sequence: G30-K439

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Platelet glycoprotein 4

Synonyms :

Platelet glycoprotein 4;Adipocyte membrane protein;Fatty acid translocase;Fatty acid transport protein;Glycoprotein IIIb;GPIIIB;PAS IV;PAS-4;Platelet glycoprotein IV;GPIV;CD36;Cd36;Fat;

Protein Name :

Platelet glycoprotein 4

Molecular Weight :

52731 MW

Protein Function :

Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport (By similarity). Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4-TLR6, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42 binding, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory signals, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Subcellular Localization :

Cell membrane; Multi-pass membrane protein. Upon ligand-binding, internalized through dynamin-dependent endocytosis.

Tissue Specificity :

Expressed at high levels in heart, intestine, spleen, adipose tissue, skeletal muscle and, at lower levels, in testes.

Background :

CD36 (Cluster of Differentiation 36) is an integral membrane protein found on the surface of many cell types in vertebrate animals and is also known as FAT, SCARB3, GP88, glycoprotein IV (gpIV) and glycoprotein IIIb (gpIIIb). The human CD36 is a member of a gene family of structurally related glycoproteins and functions as a receptor for collagen type I and thrombospondin. The use of a CD36 genomic probe has allowed the localization of the CD36 locus to the 7q11.2 band by fluorescence in situ hybridization coupled with GTG-banding. CED-1/SCARF1 and C03F11.3/CD36 are beta-glucan binding receptors and define an evolutionarily conserved pathway for the innate sensing of fungal pathogens.

Research Category :

Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Cell Type Markers, Defensin, Heart Disease, Hematopoietic Progenitors, Human Protein, Immunology, Lipid And Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Lipids And Lipoproteins, Microbiology, Pathways And Processes, Platelets, Protein, Stem Cells