Rat ADAM12 ELISA Kit PicoKine® | Boster EK1293 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat ADAM12 ELISA Kit PicoKine®

catalog :

EK1293

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1293

Product Name :

Rat ADAM12 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat ADAM12 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Adam12 in cell culture supernatants, serum and plasma (heparin). Sensitivity: 10pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

ADAM12

Uniprot ID :

F1M9Z9

Immunogen :

Expression system for standard: CHO; Immunogen sequence: R29-S513

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

ADAM metallopeptidase domain 12

Synonyms :

Protein Adam12 ;Adam12 ;

Protein Name :

Disintegrin and metalloproteinase domain-containing protein 12

Molecular Weight :

96518 MW

Sequence Similarities :

Contains 1 disintegrin domain.

Background :

ADAM12 (Disintegrin and metalloproteinase domain-containing protein 12), also known as MLTN, is an enzyme that in humans is encoded by the ADAM12 gene. This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis. By RT-PCR and immunoblot analyses that expression of mouse Adam12 increases during muscle regeneration, while the levels of other ADAMs remain constant. Immunofluorescence analysis revealed staining of small, newly formed muscle fibers in regenerating but not normal adult muscle cells. By using of fluorescence in situ hybridization, the ADAM12 gene is mapped to human chromosome 10q26.3.

Research Category :

Cancer, Cell Adhesion, Cell Biology, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Integrins, Invasion/Microenvironment, Metalloprotease, Proteolysis / Ubiquitin, Proteolytic Enzymes, Signal Transduction