Mouse DMP-1 ELISA Kit PicoKine® | Boster EK1290 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse DMP-1 ELISA Kit PicoKine®

catalog :

EK1290

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1290

Product Name :

Mouse DMP-1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse DMP-1 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Dmp1 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

DMP1

Uniprot ID :

O55188

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L17-Y503

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Dentin matrix acidic phosphoprotein 1

Synonyms :

Dentin matrix acidic phosphoprotein 1;DMP-1;Dentin matrix protein 1;AG1;Dmp1;Dmp;

Protein Name :

Dentin matrix acidic phosphoprotein 1

Molecular Weight :

53965 MW

Protein Function :

May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity).

Subcellular Localization :

Nucleus . Cytoplasm . Secreted, extracellular space, extracellular matrix . In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus (By similarity).

Tissue Specificity :

Expressed in tooth particularly in odontoblast, ameloblast and cementoblast. Also expressed in bone particularly in osteoblast.

Background :

Dentin matrix acidic phosphorprotein 1 is a protein that in humans is encoded by the DMP1 gene. It belongs to the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of secreted phosphoproteins. This gene is mapped to 4q22.1. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. In undifferentiated osteoblasts, DMP-1 is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation, the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals.

Research Category :

Cytoskeleton / Ecm, Developmental Biology, Ecm Proteins, Extracellular Matrix, Mesenchymal Stem Cells, Organogenesis, Signal Transduction, Skeletal Development, Stem Cells, Structures