Human REG-4 ELISA Kit PicoKine® | Boster EK1289 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human REG-4 ELISA Kit PicoKine®

catalog :

EK1289

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Oue N, Noguchi T, Anami K, Sentani K, Sakamoto N, Uraoka N, et al. Serum concentration and expression of Reg IV in patients with esophageal cancer: Age-related elevation of serum Reg IV concentration. Oncol Lett. 2011;2:235-239 pubmed

image

image 1 :

Human REG-4 PicoKine ELISA Kit standard curve

product information

SKU :

EK1289

Product Name :

Human REG-4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human REG-4 ELISA Kit PicoKine® (96 Tests). Quantitate Human REG4 in cell culture supernatants, serum and plasma (heparin). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

REG4

Uniprot ID :

Q9BYZ8

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: D23-P158

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Regenerating islet-derived protein 4

Synonyms :

Regenerating islet-derived protein 4;REG-4;Gastrointestinal secretory protein;REG-like protein;Regenerating islet-derived protein IV;Reg IV;REG4;GISP, RELP;

Protein Name :

Regenerating islet-derived protein 4

Molecular Weight :

18230 MW

Protein Function :

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium.

Subcellular Localization :

Secreted .

Tissue Specificity :

Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells.

Sequence Similarities :

Contains 1 C-type lectin domain.

Background :

Regenerating islet-derived protein 4 is a protein that in humans is encoded by the REG4 gene. It is mapped to 1p12. REG-4 gene contains 6 exons and that the exon structure is preserved among members of the REG gene family. This gene is able to maintain carbohydrate recognition activity in an acidic environment. REG-4 expression was significantly upregulated by inflammation and tissue injury associated with active Crohn disease and ulcerative colitis, and most of the colorectal tumors overexpressing REG-4 are mucinous tumors or neuroendocrine tumors.

Research Category :

Cancer, Immunology, Secreted Molecules, Tumor Biomarkers

more info or order :

Boster product webpage