Human CRLF2/TSLP R ELISA Kit PicoKine® | Boster EK1288 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CRLF2/TSLP R ELISA Kit PicoKine®

catalog :

EK1288

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1288

Product Name :

Human CRLF2/TSLP R ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CRLF2/TSLP R ELISA Kit PicoKine® (96 Tests). Quantitate Human CRLF2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CRLF2

Uniprot ID :

Q9HC73

Immunogen :

Expression system for standard: NS0; Immunogen sequence: G25-K231

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cytokine receptor-like factor 2

Synonyms :

Cytokine receptor-like factor 2;Cytokine receptor-like 2;IL-XR;Thymic stromal lymphopoietin protein receptor;TSLP receptor;CRLF2;CRL2, ILXR, TSLPR;

Protein Name :

Cytokine receptor-like factor 2

Molecular Weight :

42013 MW

Protein Function :

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.

Subcellular Localization :

Isoform 1: Cell membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells.

Sequence Similarities :

Belongs to the type I cytokine receptor family. Type 5 subfamily.

Background :

Cytokine receptor-like factor 2, also known as TSLPR or CRL2, is a protein that in humans is encoded by the CRLF2 gene. It is mapped to Xp22.33. The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. In addition to it, it has been found that rearrangement of CRLF2 and JAK mutation together contribute to leukemogenesis in B-progenitor ALL.

Research Category :

Cytokines, Immunology, Innate Immunity