Horse equine CXCL14 ELISA Kit PicoKine® | Boster EK1285-EQ product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Horse equine CXCL14 ELISA Kit PicoKine®

catalog :

EK1285-EQ

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1285-EQ

Product Name :

Horse equine CXCL14 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Horse equine CXCL14 ELISA Kit PicoKine® (96 Tests). Quantitate Horse CXCL14 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Equine

Application :

ELISA

Gene Name :

CXCL14

Uniprot ID :

O95715

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S35-E111

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-X-C motif chemokine 14

Synonyms :

C-X-C motif chemokine 14;Chemokine BRAK;MIP-2G;Small-inducible cytokine B14;CXCL14;MIP2G, NJAC, SCYB14;PSEC0212, UNQ240/PRO273;

Protein Name :

C-X-C motif chemokine 14

Molecular Weight :

13078 MW

Protein Function :

Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte- derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.

Sequence Similarities :

Belongs to the intercrine alpha (chemokine CxC) family.

Background :

Chemokine (C-X-C motif) ligand 14 (CXCL14) is a small cytokine belonging to the CXC chemokine family that is also known as BRAK (for breast and kidney-expressed chemokine). This gene is mapped to 5q31.1. CXCL14 is constitutively expressed at high levels in many normal tissues, it has been found that fibroblasts are the primary source of CXCL14 and that CXCL14 is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. It is also a potent chemoattractant and activator of dendritic cells, is implicated in homing of these cells, and can stimulate the migration of activated NK cells. CXCL14 also inhibits angiogenesis, possibly as a result of its ability to block endothelial cell chemotaxis. In addition to it, CXCL14 is a potent chemokine for immature DCs, with a chemoattractive activity comparable to bacterial fMLP and MIP1A.

Research Category :

Cancer, Chemokines, Immunology, Innate Immunity, Oncoproteins/Suppressors, Tumor Suppressors