product summary
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company name :
Boster
product type :
ELISA/assay
product name :
Human Corin ELISA Kit PicoKine®
catalog :
EK1283
quantity :
96 wells/kit, with removable strips.
price :
369 USD
more info or order :
citations: 3
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image
image 1 :
Human Corin PicoKine ELISA Kit standard curve
product information
SKU :
EK1283
Product Name :
Human Corin ELISA Kit PicoKine®
Size :
96 wells/kit, with removable strips.
Price :
369 USD
Description :
Human Corin ELISA Kit PicoKine® (96 Tests). Quantitate Human CORIN in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.
Reactivity :
Human
Application :
ELISA
Gene Name :
CORIN
Uniprot ID :
Q9Y5Q5
Immunogen :
Expression system for standard: NS0; Immunogen sequence: S67-N1042
Cross-reactivity :
There is no detectable cross-reactivity with other relevant proteins.
Assay Range :
62.5 pg/ml - 4,000 pg/ml
Sensitivity :
<10 pg/ml
Sample Type :
cell culture supernatants, serum and plasma (heparin, EDTA)
Capture/Detection Antibodies :
monoclonal antibody from mouse, polyclonal antibody from goat
Storage :
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Gene Full Name :
Atrial natriuretic peptide-converting enzyme
Synonyms :
Atrial natriuretic peptide-converting enzyme;3.4.21.-;Corin;Heart-specific serine proteinase ATC2;Pro-ANP-converting enzyme;Transmembrane protease serine 10;Atrial natriuretic peptide-converting enzyme, N-terminal propeptide;Atrial natriuretic peptide-converting enzyme, activated protease fragment;Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment;Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment;Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment;CORIN;CRN, TMPRSS10;
Protein Name :
Atrial natriuretic peptide-converting enzyme
Molecular Weight :
116486 MW
Protein Function :
Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
Subcellular Localization :
Cell membrane ; Single- pass type II membrane protein . May easily detached from the endothelial cell membrane.
Tissue Specificity :
Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level).
Sequence Similarities :
Belongs to the peptidase S1 family.
Background :
Atrial natriuretic peptide-converting enzyme, also called CRN or ATC2, is a protein that in humans is encoded by the CORIN gene. It is mapped to 4p12. This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. It has been found that Corin is the pro-ANP-converting enzyme and that Corin-mediated pro-ANP activation may play a role in regulating blood pressure. What’s more, Corin and ANP are essential for physiologic changes at the maternal-fetal interface. This protein may also function as a pro-brain-type natriuretic peptide convertase. Corin gene mutations which cause Corin to impair activity might be an underlying mechanism in hypertension.
Research Category :
Cardiovascular, Cell Biology, Proteolysis / Ubiquitin, Proteolytic Enzymes
more info or order :
company information
Boster
3942 B Valley Ave
Pleasanton, CA 94566
Pleasanton, CA 94566
boster@bosterbio.com
https://www.bosterbio.com925.485.4527
headquarters: USA
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