Human IL-18BP ELISA Kit PicoKine® | Boster EK1282 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IL-18BP ELISA Kit PicoKine®

catalog :

EK1282

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Shan N, Jiang Y, Sui X, Li Y, Liu X, Xu H, et al. [The study of IL-18 and IL-18BP balance in aplastic anemia]. Zhonghua Xue Ye Xue Za Zhi. 2011;32:783-5 pubmed

image

image 1 :

Human IL-18BP PicoKine ELISA Kit standard curve

product information

SKU :

EK1282

Product Name :

Human IL-18BP ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human IL-18BP ELISA Kit PicoKine® (96 Tests). Quantitate Human IL18BP in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IL18BP

Uniprot ID :

O95998

Immunogen :

Expression system for standard: NS0; Immunogen sequence: T31-G194

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.7 pg/ml - 6,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA) and urine

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-18-binding protein

Synonyms :

Interleukin-18-binding protein;IL-18BP;Tadekinig-alfa;IL18BP;

Protein Name :

Interleukin-18-binding protein

Molecular Weight :

21099 MW

Protein Function :

Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response.

Subcellular Localization :

Secreted .

Tissue Specificity :

Strongly expressed in heart, lung, placenta and spleen.

Sequence Similarities :

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Background :

Interleukin-18-binding protein, also known as IL18BPa, is a protein that in humans is encoded by the IL18BP gene. It is mapped to 11q13.4. The protein encoded by this gene is an inhibitor of the proinflammatory cytokine IL18. This protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. This protein is constitutively expressed and secreted in mononuclear cells. The expression of this protein can be enhanced by IFN-gamma. It has been found that IL18BP expression in intestinal tissue is increased in endothelial cells as well as cells of the submucosa and overlying lymphoid aggregates in Crohn disease.

Research Category :

Immunology, Innate Immunity, Cytokines, Interleukins

more info or order :

Boster product webpage