Human LBP ELISA Kit PicoKine® | Boster EK1271 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human LBP ELISA Kit PicoKine®

catalog :

EK1271

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1271

Product Name :

Human LBP ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human LBP ELISA Kit PicoKine® (96 Tests). Quantitate Human LBP in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

LBP

Uniprot ID :

P18428

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A26-V481

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.78 ng/ml - 50 ng/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Lipopolysaccharide-binding protein

Synonyms :

Lipopolysaccharide-binding protein;LBP;LBP;

Protein Name :

Lipopolysaccharide-binding protein

Molecular Weight :

53384 MW

Protein Function :

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).

Subcellular Localization :

Secreted . Cytoplasmic granule membrane . Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.

Tissue Specificity :

Detected in blood serum (at protein level).

Sequence Similarities :

Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.

Background :

Lipopolysaccharide binding protein is a protein that in humans is encoded by the LBP gene. This gene is mapped to 20q11.23. LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or LPS) to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4. It is present in the cerebrospinal fluid of patients with pneumococcal meningitis. The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. LBP is made in the liver during the acute phase of infections and is thought to function as a carrier for LPS and to help control LPS-dependent monocyte responses.

Research Category :

Defensin, Human Protein, Immunology, Innate Immunity, Macrophage / Inflamm., Microbiology, Protein, Tlr Signaling