Human IL-18R1 ELISA Kit PicoKine® | Boster EK1260 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IL-18R1 ELISA Kit PicoKine®

catalog :

EK1260

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1260

Product Name :

Human IL-18R1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human IL-18R1 ELISA Kit PicoKine® (96 Tests). Quantitate Human IL18R1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IL18R1

Uniprot ID :

Q13478

Immunogen :

Expression system for standard: NS0; Immunogen sequence: C22-R329

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-18 receptor 1

Synonyms :

Interleukin-18 receptor 1;IL-18R-1;IL-18R1;CD218 antigen-like family member A;CDw218a;IL1 receptor-related protein;IL-1Rrp;IL1R-rp;CD218a;IL18R1;IL1RRP;

Protein Name :

Interleukin-18 receptor 1

Molecular Weight :

62304 MW

Protein Function :

Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines.

Sequence Similarities :

Belongs to the interleukin-1 receptor family.

Background :

The interleukin-18 receptor 1 (IL-18R1), also known as CDw218a (cluster of differentiation w218a) or IL18RA, is an interleukin receptor of the immunoglobulin superfamily. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells.

Research Category :

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage / Inflamm.