Human Ficolin-2 ELISA Kit PicoKine® | Boster EK1258 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Ficolin-2 ELISA Kit PicoKine®

catalog :

EK1258

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 2

Reference
Schaffer T, Schoepfer A, Seibold F. Serum ficolin-2 correlates worse than fecal calprotectin and CRP with endoscopic Crohn's disease activity. J Crohns Colitis. 2014;8:1125-32 pubmed publisher
Hu Y, Luo F, Fu J, Chen T, Wu S, Zhou Y, et al. Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients. Scand J Immunol. 2013;77:144-50 pubmed publisher

image

image 1 :

Human Ficolin-2 PicoKine ELISA Kit standard curve

product information

SKU :

EK1258

Product Name :

Human Ficolin-2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human Ficolin-2 ELISA Kit PicoKine® (96 Tests). Quantitate Human FCN2 in cell culture supernatants, serum and plasma (heparin). Sensitivity: 20pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

FCN2

Uniprot ID :

Q15485

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L26-A313

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.78 ng/ml - 50 ng/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Ficolin-2

Synonyms :

Ficolin-2;37 kDa elastin-binding protein;Collagen/fibrinogen domain-containing protein 2;EBP-37;Ficolin-B;Ficolin-beta;Hucolin;L-ficolin;Serum lectin p35;FCN2;FCNL;

Protein Name :

Ficolin-2

Molecular Weight :

34001 MW

Protein Function :

May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed by the liver and secreted in plasma.

Sequence Similarities :

Belongs to the ficolin lectin family.

Background :

Ficolin-2, which was initially identified as L-ficolin, is a protein that in humans is encoded by the FCN2 gene. The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. It is mapped to 9q34.3. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Serum concentration of ficolin-2 varies considerably in healthy individuals. FCN2 promoter polymorphisms were associated with marked changes in theficolin-2 serum concentration.

Research Category :

Cardiovascular, Immunology, Secreted Molecules, Serum Proteins

more info or order :

Boster product webpage