Human CD320 / 8D6A / TCblR ELISA Kit PicoKine® | Boster EK1255 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CD320 / 8D6A / TCblR ELISA Kit PicoKine®

catalog :

EK1255

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Arendt J, Quadros E, Nexo E. Soluble transcobalamin receptor, sCD320, is present in human serum and relates to serum cobalamin - establishment and validation of an ELISA. Clin Chem Lab Med. 2011;50:515-9 pubmed publisher

image

image 1 :

Human CD320/8D6A PicoKine ELISA Kit standard curve

product information

SKU :

EK1255

Product Name :

Human CD320 / 8D6A / TCblR ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human CD320 / 8D6A / TCblR ELISA Kit PicoKine® (96 Tests). Quantitate Human CD320 in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CD320

Uniprot ID :

Q9NPF0

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S36-Y229

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA) and urine

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

CD320 antigen

Synonyms :

CD320 antigen;8D6 antigen;FDC-signaling molecule 8D6;FDC-SM-8D6;Transcobalamin receptor;TCblR;CD320;CD320;8D6A;UNQ198/PRO224;

Protein Name :

CD320 antigen

Molecular Weight :

28991 MW

Protein Function :

Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.

Subcellular Localization :

Membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Expressed abundantly on follicular dendritic cells (FDCs).

Background :

CD320 (cluster of differentiation 320), also known as 8D6A or TCBLR, is a human gene. It is mapped to chromosome 19p13.2. This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and the expression of CD320 enhanced B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. It has been found that antagonists of the CD320 signaling pathway may counter the growth of follicular lymphomas or other tumors that metastasize to lymphoid follicles. CD320 is also a specific receptor for uptake of TCN2-bound cobalamin.

Research Category :

Adaptive Immunity, B Cells, Cell Biology, Cell Cycle, Cell Differentiation, Developmental Biology, Immunology, Organogenesis

more info or order :

Boster product webpage