Human Renin / Prorenin ELISA Kit PicoKine® | Boster EK1249 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Renin / Prorenin ELISA Kit PicoKine®

catalog :

EK1249

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1249

Product Name :

Human Renin / Prorenin ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Renin / Prorenin ELISA Kit PicoKine® (96 Tests). Quantitate Human REN in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

REN

Uniprot ID :

P00797

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L67-R406

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA) and urine

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Renin

Synonyms :

Renin;3.4.23.15;Angiotensinogenase;REN;

Protein Name :

Renin

Molecular Weight :

45057 MW

Protein Function :

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Subcellular Localization :

Secreted. Membrane. Associated to membranes via binding to ATP6AP2.

Sequence Similarities :

Belongs to the peptidase A1 family.

Background :

Renin, also known as an angiotensinogenase, is an enzyme that participates in the body's renin-angiotensin system (RAS). This gene is mapped to 1q32.1. Renin's primary function is to cause an increase in blood pressure, leading to restoration of perfusion pressure in the kidneys. It also can catalyze the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. What's more, Renin secretion is also stimulated by sympathetic nervous stimulation, mainly through beta-1 adrenoceptor activation.

Research Category :

Metabolism, Pathways And Processes, Signal Transduction, Vitamins / Minerals