Mouse FOLR1/Alpha Fr ELISA Kit PicoKine® | Boster EK1243 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse FOLR1/Alpha Fr ELISA Kit PicoKine®

catalog :

EK1243

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1243

Product Name :

Mouse FOLR1/Alpha Fr ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse FOLR1/Alpha Fr ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Folr1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

FOLR1

Uniprot ID :

P35846

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: T25-S232

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

46.9 pg/ml - 3,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Folate receptor alpha

Synonyms :

Folate receptor alpha;FR-alpha;Folate receptor 1;Folate-binding protein 1;Folr1;Fbp1, Folbp1;

Protein Name :

Folate receptor alpha

Molecular Weight :

29449 MW

Protein Function :

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.

Subcellular Localization :

Cell membrane; Lipid-anchor, GPI-anchor. Secreted . Cytoplasmic vesicle . Cytoplasmic vesicle, clathrin-coated vesicle . Endosome . Apical cell membrane. Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane (By similarity). Detected at proximal tubule apical membranes.

Tissue Specificity :

Detected in kidney proximal tubules (at protein level).

Background :

Folate receptor 1 adult is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family. It is mapped to 11q13.4. FOLR1 expression in Jurkat cells facilitated MBG or EBO entry, and FR-blocking reagents inhibited infection of MBG or EBO. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. The FOLR1 gene encodes the adult folate receptor, or folate-binding protein (FBP), which has a high affinity for folic acid and for several reduced folic acid derivatives, and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. FOLR1 is also an important regulator of milk protein synthesis.

Research Category :

Cell Type Markers, Tags & Cell Markers, Tumor Associated