Human FOLR1/Alpha Fr ELISA Kit PicoKine® | Boster EK1242 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human FOLR1/Alpha Fr ELISA Kit PicoKine®

catalog :

EK1242

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Leung F, Dimitromanolakis A, Kobayashi H, Diamandis E, Kulasingam V. Folate-receptor 1 (FOLR1) protein is elevated in the serum of ovarian cancer patients. Clin Biochem. 2013;46:1462-8 pubmed publisher

image

image 1 :

Human FOLR1 PicoKine ELISA Kit standard curve

product information

SKU :

EK1242

Product Name :

Human FOLR1/Alpha Fr ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human FOLR1/Alpha Fr ELISA Kit PicoKine® (96 Tests). Quantitate Human FOLR1 in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

FOLR1

Uniprot ID :

P15328

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: R25-S234

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

46.9 pg/ml - 3,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva, urine and human milk

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Folate receptor alpha

Synonyms :

Folate receptor alpha;FR-alpha;Adult folate-binding protein;FBP;Folate receptor 1;Folate receptor, adult;KB cells FBP;Ovarian tumor-associated antigen MOv18;FOLR1;FOLR;

Protein Name :

Folate receptor alpha

Molecular Weight :

29819 MW

Protein Function :

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Subcellular Localization :

Cell membrane; Lipid-anchor, GPI-anchor. Secreted . Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane . Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane.

Tissue Specificity :

Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.

Background :

Folate receptor 1 adult is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family. It is mapped to 11q13.4. FOLR1 expression in Jurkat cells facilitated MBG or EBO entry, and FR-blocking reagents inhibited infection of MBG or EBO. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. The FOLR1 gene encodes the adult folate receptor, or folate-binding protein (FBP), which has a high affinity for folic acid and for several reduced folic acid derivatives, and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. FOLR1 is also an important regulator of milk protein synthesis.

Research Category :

Cell Type Markers, Tags & Cell Markers, Tumor Associated

more info or order :

Boster product webpage