Human SHBG / Sex Hormone Binding Globulin ELISA Kit PicoKine®

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human SHBG / Sex Hormone Binding Globulin ELISA Kit PicoKine®

catalog :

EK1236

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1236

Product Name :

Human SHBG / Sex Hormone Binding Globulin ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human SHBG / Sex Hormone Binding Globulin ELISA Kit PicoKine® (96 Tests). Quantitate Human SHBG in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 0.001 nmol/L.

Reactivity :

Human

Application :

ELISA

Gene Name :

SHBG

Uniprot ID :

P04278

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L30-H402

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.031 nmol/L - 2 nmol/L

Sensitivity :

<0.001 nmol/L

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Sex hormone-binding globulin

Synonyms :

Sex hormone-binding globulin;SHBG;Sex steroid-binding protein;SBP;Testis-specific androgen-binding protein;ABP;Testosterone-estradiol-binding globulin;TeBG;Testosterone-estrogen-binding globulin;SHBG;

Protein Name :

Sex hormone-binding globulin

Molecular Weight :

43779 MW

Protein Function :

Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.

Subcellular Localization :

Secreted . In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis.

Tissue Specificity :

Isoform 1 and isoform 2 are present in liver and testis.

Sequence Similarities :

Contains 2 laminin G-like domains.

Background :

Sex hormone-binding globulin (SHBG) or sex steroid-binding globulin (SSBG) is a glycoprotein that binds to the two sex hormones: androgen and estrogen. The gene for SHBG is located on chromosome 17 on the short arm between the bands 17p12→p13. And this gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants.

Research Category :

Cancer, Growth Factors/Hormones, Lipid Metabolism, Metabolism, Signal Transduction