Human TNFRSF14/HVEM ELISA Kit PicoKine® | Boster EK1226 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TNFRSF14/HVEM ELISA Kit PicoKine®

catalog :

EK1226

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Kotani H, Masuda K, Tamagawa Mineoka R, Nomiyama T, Soga F, Nin M, et al. Increased plasma LIGHT levels in patients with atopic dermatitis. Clin Exp Immunol. 2012;168:318-24 pubmed publisher

image

image 1 :

Human TNFRSF14/HVEM PicoKine ELISA Kit standard curve

product information

SKU :

EK1226

Product Name :

Human TNFRSF14/HVEM ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human TNFRSF14/HVEM ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF14 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 1pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFRSF14

Uniprot ID :

Q92956

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L39-V202

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 14

Synonyms :

Tumor necrosis factor receptor superfamily member 14;Herpes virus entry mediator A;Herpesvirus entry mediator A;HveA;Tumor necrosis factor receptor-like 2;TR2;CD270;TNFRSF14;HVEA, HVEM;UNQ329/PRO509;

Protein Name :

Protein Tnfrsf14

Molecular Weight :

30392 MW

Protein Function :

Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.

Subcellular Localization :

Membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Widely expressed, with the highest expression in lung, spleen and thymus.

Sequence Similarities :

Contains 3 TNFR-Cys repeats.

Background :

Tumor necrosis factor receptor superfamily member 14 (TNFRSF14), also known as HVEM, is a protein that in humans is encoded by the TNFRSF14 gene. The protein encoded by this gene is a member of the TNF-receptor superfamily. It is mapped to 1p36.32. HVEM plays an important role in HSV pathogenesis because it enhanced the entry of several wildtype HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T cells. HVEM and BTLA which are form a bidirectional signaling pathway can regulate cell survival and inhibitory responses between interacting cells. HVEM as an important orchestrator of mucosal immunity integrates signals from innate lymphocytes to induce optimal epithelial Stat3 activation, which indicated that targeting HVEM with agonists could improve host defense.

Research Category :

Antiviral Signaling, Cancer, Cytokines, Growth Factors, Growth Factors/Hormones, Immune System Diseases, Immunology, Innate Immunity, Signal Transduction, Tnf Superfamily

more info or order :

Boster product webpage