Human CCL23/MPIF-1 ELISA Kit PicoKine® | Boster EK1224 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CCL23/MPIF-1 ELISA Kit PicoKine®

catalog :

EK1224

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Yanaba K, Yoshizaki A, Muroi E, Ogawa F, Asano Y, Kadono T, et al. Serum CCL23 levels are increased in patients with systemic sclerosis. Arch Dermatol Res. 2011;303:29-34 pubmed publisher

image

image 1 :

Human CCL23/MPIF-1 PicoKine ELISA Kit standard curve

product information

SKU :

EK1224

Product Name :

Human CCL23/MPIF-1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human CCL23/MPIF-1 ELISA Kit PicoKine® (96 Tests). Quantitate Human CCL23 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 2pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CCL23

Uniprot ID :

P55773

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: R22-N120

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<2 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-C motif chemokine 23

Synonyms :

C-C motif chemokine 23;CK-beta-8;CKB-8;Macrophage inflammatory protein 3;MIP-3;Myeloid progenitor inhibitory factor 1;MPIF-1;Small-inducible cytokine A23;CCL23 (19-99);CCL23 (22-99);CCL23 (27-99);CCL23 (30-99);CCL23;MIP3, MPIF1, SCYA23;

Protein Name :

C-C motif chemokine 23

Molecular Weight :

13411 MW

Protein Function :

Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23 (19-99), CCL23 (22-99), CCL23 (27-99), CCL23 (30-99) are more potent chemoattractants than the small-inducible cytokine A23.

Subcellular Localization :

Secreted.

Tissue Specificity :

High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. The short form is the major species and the longer form was detected only in very low abundance. CCL23 (19-99), CCL23 (22-99), CCL23 (27-99), CCL23 (30-99) are found in high levels in synovial fluids from rheumatoid patients.

Sequence Similarities :

Belongs to the intercrine beta (chemokine CC) family.

Background :

Chemokine (C-C motif) ligand 23 (CCL23), also known as MIP-3 and MPIF-1, is a small cytokine belonging to the CC chemokine family. It is mapped to 17q12. CCL23 is predominantly expressed in lung and liver tissue, but is also found in placenta, bone marrow and some cell lines of myeloid origin. MPIF1 has chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils. It has also been attributed to an inhibitory activity on hematopoietic progenitor cells that give rise to granulocyte and monocyte lineages. Moreover, CCL23 is a ligand for the chemokine receptor CCR1.

Research Category :

Chemokines, G Protein Signaling, Immunology, Innate Immunity, Macrophage / Inflamm., Signal Transduction, Signaling Pathway

more info or order :

Boster product webpage