Mouse uPAR / uPA Receptor ELISA Kit PicoKine® | Boster EK1215 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse uPAR / uPA Receptor ELISA Kit PicoKine®

catalog :

EK1215

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1215

Product Name :

Mouse uPAR / uPA Receptor ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse uPAR / uPA Receptor ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Plaur in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 5pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

PLAUR

Uniprot ID :

P35456

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L24-T297

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<5 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Urokinase plasminogen activator surface receptor

Synonyms :

Urokinase plasminogen activator surface receptor;U-PAR;uPAR;CD87;Plaur;

Protein Name :

Urokinase plasminogen activator surface receptor

Molecular Weight :

35428 MW

Protein Function :

Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA.

Subcellular Localization :

Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor.

Tissue Specificity :

Expressed in angiogenic endothelial cells (at protein level).

Background :

The urokinase-type plasminogen activator receptor (uPAR) is a key molecule in the regulation of cell-surface plasminogen activation and, as such, plays an important role in many normal as well as pathological processes.1 The cDNA for Mo3, an activation antigen expressed by human monocytes and myelomonocytic cell lines after stimulation by a variety of agents. Mo3 expression in vivo is associated predominantly with macrophages in inflammatory sites. It is a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. The complete coding sequence of the cDNA has been found to encode 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. Mo3 is identical to the human receptor for the urokinase plasminogen activator.2 UPAR is a useful prognostic marker for biologically aggressive forms of endometrial cancer.3 PLAUR is located at chromosome 19q13.1-q13.2.1

Research Category :

Invasion/Microenvironment, Receptors, Tumor Biomarkers