Human Cystatin B/CSTB ELISA Kit PicoKine® | Boster EK1205 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Cystatin B/CSTB ELISA Kit PicoKine®

catalog :

EK1205

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1205

Product Name :

Human Cystatin B/CSTB ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Cystatin B ELISA Kit PicoKine® (96 Tests). Quantitate Human CSTB in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CSTB

Uniprot ID :

P04080

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: M2-F98

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva, urine and human milk

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cystatin-B

Synonyms :

Cystatin-B;CPI-B;Liver thiol proteinase inhibitor;Stefin-B;CSTB;CST6, STFB;

Protein Name :

Cystatin-B

Molecular Weight :

11140 MW

Protein Function :

This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B.

Subcellular Localization :

Cytoplasm . Nucleus .

Sequence Similarities :

Belongs to the cystatin family.

Background :

Cystatin B (CSTB), also called STFB, is a small protein that is a member of the superfamily of cysteine protease inhibitors. It has been isolated from human spleen and liver and its amino acid sequence has been fully determined. The cystatin B gene is located on 21q22.3. It is widely distributed and is localized mostly intracellularly, but has been found extracellularly. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Its role is thought to be as a protector against the proteinases leaking from lysosomes. A cystatin B multiprotein complex might have a specific cerebellar function, and that the loss of this function might contribute to the etiopathogenesis of EPM1. Upon differentiation to myotubes, CSTB becomes excluded from the nucleus and lysosomes, suggesting that the subcellular distribution of CSTB is dependent on the differentiation status of the cell.

Research Category :

Cell Biology, Protease Inhibitors, Proteolysis / Ubiquitin