Human LIFR/Lif R Alpha ELISA Kit PicoKine® | Boster EK1200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human LIFR/Lif R Alpha ELISA Kit PicoKine®

catalog :

EK1200

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1200

Product Name :

Human LIFR/Lif R Alpha ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human LIFR/Lif R Alpha ELISA Kit PicoKine® (96 Tests). Quantitate Human LIFR in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

LIFR

Uniprot ID :

P42702

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q45-S833

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Leukemia inhibitory factor receptor

Synonyms :

Leukemia inhibitory factor receptor;LIF receptor;LIF-R;CD118;LIFR;

Protein Name :

Leukemia inhibitory factor receptor

Molecular Weight :

123743 MW

Protein Function :

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

Subcellular Localization :

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Sequence Similarities :

Belongs to the type I cytokine receptor family. Type 2 subfamily.

Background :

LIFR, also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. This gene encodes a protein that belongs to the type I cytokine receptor family. It is mapped to 5p31.1. The LIF receptor (LIFR) is the low-affinity binding chain that, together with the high-affinity converter subunit gp130, forms a high-affinity receptor complex that mediates the action of the leukemia-inhibitory factor. LIF is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, togerther with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland.

Research Category :

Cell Type Markers, Cytokines, Developmental Biology, Embryogenesis, Embryonic Stem Cells, Immunology, Innate Immunity, Intracellular, Stem Cells, Surface Molecules