Mouse Periostin/OSF2 ELISA Kit PicoKine® | Boster EK1187 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse Periostin/OSF2 ELISA Kit PicoKine®

catalog :

EK1187

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1187

Product Name :

Mouse Periostin/OSF2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse Periostin/OSF2 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Postn in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

POSTN

Uniprot ID :

Q62009

Immunogen :

Expression system for standard: NS0; Immunogen sequence: N24-Q836

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.7 pg/ml - 6,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Periostin

Synonyms :

Periostin;PN;Osteoblast-specific factor 2;OSF-2;Postn;Osf2;

Protein Name :

Periostin

Molecular Weight :

93144 MW

Protein Function :

Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX.

Subcellular Localization :

Golgi apparatus. Secreted, extracellular space, extracellular matrix. Colocalizes with BMP1 in the Golgi.

Tissue Specificity :

Preferentially expressed in periosteum and periodontal ligament. Also expressed in the developing and adult heart.

Sequence Similarities :

Contains 1 EMI domain.

Background :

Periostin, also known as OSF2, is a protein that in humans is encoded by the POSTN gene. The International Radiation Hybrid Mapping Consortium mapped the POSTN gene to chromosome 13. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/ beta-5 integrins to support adhesion and migration of epithelial cells. It is found that periostin was overexpressed by the majority of human primary breast cancers examined. After myocardial infarction, periostin-induced cardiomyocyte cell cycle reentry and mitosis were associated with improved ventricular remodeling and myocardial function, reduced fibrosis and infarct size, and increase angiogenesis.

Research Category :

Atherosclerosis, Cancer, Cardiogenesis, Cardiovascular, Cell Adhesion Molecules, Cell Type Markers, Cytoskeleton / Ecm, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Structures, Tags & Cell Markers, Vascular Inflammation