Human KLK11/Kallikrein-11 ELISA Kit PicoKine® | Boster EK1166 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human KLK11/Kallikrein-11 ELISA Kit PicoKine®

catalog :

EK1166

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1166

Product Name :

Human KLK11/Kallikrein-11 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human KLK11/Kallikrein 11 ELISA Kit PicoKine® (96 Tests). Quantitate Human KLK11 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

KLK11

Uniprot ID :

Q9UBX7

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E19-N250

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Kallikrein-11

Synonyms :

Kallikrein-11;hK11;3.4.21.-;Hippostasin;Serine protease 20;Trypsin-like protease;Kallikrein-11 inactive chain 1;Kallikrein-11 inactive chain 2;KLK11;PRSS20, TLSP;UNQ649/PRO1279;

Protein Name :

Kallikrein-11

Molecular Weight :

31059 MW

Protein Function :

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

Subcellular Localization :

Isoform 1: Secreted.

Tissue Specificity :

Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate. Present in seminal plasma at concentrations ranging from 2 to 37 microg/mL (at protein level).

Background :

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms which are differentially expressed.

Research Category :

Cancer, Cell Biology, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis / Ubiquitin, Proteolytic Enzymes, Signal Transduction