Rat N-Cadherin-2 CDH2 CD325 ELISA Kit PicoKine® | Boster EK1156 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat N-Cadherin-2 CDH2 CD325 ELISA Kit PicoKine®

catalog :

EK1156

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1156

Product Name :

Rat N-Cadherin-2 CDH2 CD325 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat N-Cadherin-2 CDH2 CD325 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Cdh2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 20pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

CDH2

Uniprot ID :

Q9Z1Y3

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D160-A724

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.78 ng/ml - 50 ng/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cadherin-2

Synonyms :

Cadherin-2;Neural cadherin;N-cadherin;CD325;Cdh2;

Protein Name :

Cadherin-2

Molecular Weight :

99686 MW

Protein Function :

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein .

Tissue Specificity :

In testis, expressed in Sertoli and germ cells.

Background :

Cadherin-2 (CDH2), also known as neural cadherin (NCAD), is a protein that in humans is encoded by the CDH2 gene. It is a classical cadherin from the cadherin superfamily. This gene is mapped to 18q12.1. Cadherin-2 is expressed in the brain, skeletal and cardiac muscle. Cadherin-2 is commonly found in cancer cells and provides a mechanism for transendothelial migration. It is a calcium dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Research Category :

Cadherins, Cell Adhesion, Cytoskeleton / Ecm, Signal Transduction