Mouse N-Cadherin-2 CDH2 CD325 ELISA Kit PicoKine® | Boster EK1155 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse N-Cadherin-2 CDH2 CD325 ELISA Kit PicoKine®

catalog :

EK1155

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1155

Product Name :

Mouse N-Cadherin-2 CDH2 CD325 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse N-Cadherin-2 CDH2 CD325 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Cdh2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 20pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CDH2

Uniprot ID :

P15116

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D160-A724

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.78 ng/ml - 50 ng/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cadherin-2

Synonyms :

Cadherin-2;Neural cadherin;N-cadherin;CD325;Cdh2;

Protein Name :

Cadherin-2

Molecular Weight :

99796 MW

Protein Function :

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence (PubMed:24952463). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.

Subcellular Localization :

Cell membrane; Single-pass type I membrane protein.

Background :

Cadherin-2 (CDH2), also known as neural cadherin (NCAD), is a protein that in humans is encoded by the CDH2 gene. It is a classical cadherin from the cadherin superfamily. This gene is mapped to 18q12.1. Cadherin-2 is expressed in the brain, skeletal and cardiac muscle. Cadherin-2 is commonly found in cancer cells and provides a mechanism for transendothelial migration. It is a calcium dependent cell-cell adhesion glycoprotein comprising five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Research Category :

Cadherins, Cell Adhesion, Cytoskeleton / Ecm, Signal Transduction