Mouse CD163 ELISA Kit PicoKine® | Boster EK1146 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse CD163 ELISA Kit PicoKine®

catalog :

EK1146

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1146

Product Name :

Mouse CD163 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse CD163 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Cd163 in cell culture supernatants, serum and plasma (heparin). Sensitivity: 20pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CD163

Uniprot ID :

Q2VLH6

Immunogen :

Expression system for standard: NS0; Immunogen sequence: V39-T1045

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.78 ng/ml - 50 ng/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Scavenger receptor cysteine-rich type 1 protein M130

Synonyms :

Scavenger receptor cysteine-rich type 1 protein M130;CD163;Soluble CD163;sCD163;Cd163;M130;

Protein Name :

Scavenger receptor cysteine-rich type 1 protein M130

Molecular Weight :

120921 MW

Protein Function :

Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium- dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).

Subcellular Localization :

Soluble CD163: Secreted .

Tissue Specificity :

Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen and mesenteric lymph nodes.

Background :

CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. It has also been shown to mark cells of monocyte/macrophage lineage. CD163, a member of the scavenger receptor cysteine-rich (SRCR) superfamily, is exclusively expressed by monocytes and macrophages. Using FISH, somatic cell hybrid analysis, and radiation hybrid analysis, CD163 gene was mapped the to chromosome 12p13.3. CD163 is upregulated in a large range of diseases inflammatory diseases including type 2 diabetes, macrophage activation sickness, Tangier's disease, reumatoid arthritis etc.

Research Category :

Atherosclerosis, Cardiovascular, Cell Type Markers, Immunology, Innate Immunity, Macrophage / Inflamm., Vascular Inflammation