Human PON1/Paraoxonase 1 ELISA Kit PicoKine® | Boster EK1141 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human PON1/Paraoxonase 1 ELISA Kit PicoKine®

catalog :

EK1141

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
El Lebedy D, Kafoury M, Abd El Haleem D, Ibrahim A, Awadallah E, Ashmawy I. Paraoxonase-1 gene Q192R and L55M polymorphisms and risk of cardiovascular disease in Egyptian patients with type 2 diabetes mellitus. J Diabetes Metab Disord. 2014;13:124 pubmed publisher

image

image 1 :

Human PON1 PicoKine ELISA Kit standard curve

product information

SKU :

EK1141

Product Name :

Human PON1/Paraoxonase 1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human PON1/Paraoxonase 1 ELISA Kit PicoKine® (96 Tests). Quantitate Human PON1 in cell culture supernatants, cell lysates, serum and plasma (heparin). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

PON1

Uniprot ID :

P27169

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A2-L355

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Serum paraoxonase/arylesterase 1

Synonyms :

Serum paraoxonase/arylesterase 1;PON 1;3.1.1.2;3.1.1.81;3.1.8.1;Aromatic esterase 1;A-esterase 1;K-45;Serum aryldialkylphosphatase 1;PON1;PON;

Protein Name :

Serum paraoxonase/arylesterase 1

Molecular Weight :

39731 MW

Protein Function :

Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.

Subcellular Localization :

Secreted, extracellular space.

Tissue Specificity :

Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.

Sequence Similarities :

Belongs to the paraoxonase family.

Background :

Serum paraoxonase/arylesterase 1 (PON1) also known as aromatic esterase 1 or serum aryldialkylphosphatase 1 is an enzyme that in humans is encoded by the PON1 gene. The PON gene was mapped to chromosome 7q21-q22, and the mouse Pon1 gene was mapped to the proximal end of chromosome 6. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the PON1 gene significantly affect the catalytic ability of the enzyme. PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein (HDL).

Research Category :

Atherosclerosis, Cancer, Cardiovascular, Cell Biology, Diabetes, Diabetes Associated, Drug Metabolism, Heart Disease, Lipid And Lipoprotein Metabolism, Lipid Metabolism, Lipids / Lipoproteins, Metabolic Signaling Pathways, Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Oxidative Stress, Pathways And Processes, Redox Metabolism, Signal Transduction

more info or order :

Boster product webpage