Mouse TLR2/Toll-like receptor 2 ELISA Kit PicoKine® | Boster EK1130 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse TLR2/Toll-like receptor 2 ELISA Kit PicoKine®

catalog :

EK1130

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1130

Product Name :

Mouse TLR2/Toll-like receptor 2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse TLR2/Toll-like receptor 2 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Tlr2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

TLR2

Uniprot ID :

Q9QUN7

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q25-L590

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Toll-like receptor 2

Synonyms :

Toll-like receptor 2;CD282;Tlr2;

Protein Name :

Toll-like receptor 2

Molecular Weight :

89449 MW

Protein Function :

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins (By similarity).

Subcellular Localization :

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein.

Tissue Specificity :

Detected in a macrophage cell line, smooth muscle, lung, spleen, thymus, brain and adipose tissue.

Sequence Similarities :

Belongs to the Toll-like receptor family.

Background :

Toll-like receptor 2 also known as TLR-2 is a protein that in humans is encoded by the TLR2 gene. TLR2 has also been designated as CD282 (cluster of differentiation 282). TLR-2 plays a role in the immune system. TLR-2 is a membrane protein, a receptor, which is expressed on the surface of certain cells and recognizes foreign substances and passes on appropriate signals to the cells of the immune system. TLR2 expresses as 4- and 4.4-kb mRNAs in heart, brain, and muscle.

Research Category :

Adapters, Atherosclerosis, Cardiovascular, Defensin, Human Protein, Immunoglobulins, Immunology, Innate Immunity, Macrophage / Inflamm., Microbiology, Protein, Receptors, Signal Transduction, Tlr Signaling, Transmembrane, Vascular Inflammation