Human TLR1/TIL ELISA Kit PicoKine® | Boster EK1129 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TLR1/TIL ELISA Kit PicoKine®

catalog :

EK1129

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1129

Product Name :

Human TLR1/TIL ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TLR1 / TIL ELISA Kit PicoKine® (96 Tests). Quantitate Human TLR1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TLR1

Uniprot ID :

Q15399

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S22-N578

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Toll-like receptor 1

Synonyms :

Toll-like receptor 1;Toll/interleukin-1 receptor-like protein;TIL;CD281;TLR1;KIAA0012;

Protein Name :

Toll-like receptor 1

Molecular Weight :

90291 MW

Protein Function :

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

Sequence Similarities :

Belongs to the Toll-like receptor family.

Background :

TLR1 is a member of the Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system. TIR1 gene was mapped to 4p14 by fluorescence in situ hybridization. TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria. TLR1 has also been designated as CD281 (cluster of differentiation 281). TLR1 interacts with TLR2 to recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.

Research Category :

Adapters, Immunoglobulins, Immunology, Innate Immunity, Macrophage / Inflamm., Nfkb Pathway, Nuclear Signaling, Receptors, Signal Transduction, Signaling Pathway, Tlr Signaling, Transmembrane