Mouse CCL12/MCP5 ELISA Kit PicoKine® | Boster EK1128 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse CCL12/MCP5 ELISA Kit PicoKine®

catalog :

EK1128

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1128

Product Name :

Mouse CCL12/MCP5 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse CCL12/MCP5 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl12 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

Ccl12

Uniprot ID :

Q62401

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: G23-G104

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-C motif chemokine 12

Synonyms :

C-C motif chemokine 12;MCP-1-related chemokine;Monocyte chemoattractant protein 5;Monocyte chemotactic protein 5;MCP-5;Small-inducible cytokine A12;Ccl12;Mcp5, Scya12;

Protein Name :

C-C motif chemokine 12

Molecular Weight :

11659 MW

Protein Function :

Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.

Subcellular Localization :

Secreted.

Tissue Specificity :

Predominantly expressed in the lymph nodes and thymus. Also found in the salivary glands containing lymph nodes, breast, heart, lung, brain, small intestine, kidney and colon.

Background :

Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attracts eosinophils, monocytes and lymphocytes. This chemokine is found predominately in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages. It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11.

Research Category :

Chemokines, Immunology, Innate Immunity