Human CCL16/HCC-4 ELISA Kit PicoKine® | Boster EK1127 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CCL16/HCC-4 ELISA Kit PicoKine®

catalog :

EK1127

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Arakelyan A, Kriegova E, Kubistova Z, Mrazek F, Kverka M, du Bois R, et al. Protein levels of CC chemokine ligand (CCL)15, CCL16 and macrophage stimulating protein in patients with sarcoidosis. Clin Exp Immunol. 2009;155:457-65 pubmed publisher

image

image 1 :

Human CCL16/HCC-4 PicoKine ELISA Kit standard curve

product information

SKU :

EK1127

Product Name :

Human CCL16/HCC-4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human CCL16/HCC-4 ELISA Kit PicoKine® (96 Tests). Quantitate Human CCL16 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CCL16

Uniprot ID :

O15467

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: Q24-Q120

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

7.8 pg/ml - 500 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-C motif chemokine 16

Synonyms :

C-C motif chemokine 16;Chemokine CC-4;HCC-4;Chemokine LEC;IL-10-inducible chemokine;LCC-1;Liver-expressed chemokine;Lymphocyte and monocyte chemoattractant;LMC;Monotactin-1;MTN-1;NCC-4;Small-inducible cytokine A16;CCL16;ILINCK, NCC4, SCYA16;

Protein Name :

C-C motif chemokine 16

Molecular Weight :

13600 MW

Protein Function :

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

Subcellular Localization :

Secreted.

Tissue Specificity :

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Sequence Similarities :

Belongs to the intercrine beta (chemokine CC) family.

Background :

Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This chemokine is expressed by the liver, thymus, and spleen and is chemoattractive for monocytes and lymphocytes. Cellular expression of CCL16 can be strongly induced in monocytes by IL-10, IFN-gamma and bacterial lipopolysaccharide. Its gene is located on chromosome 17, in humans, among a cluster of other CC chemokines. CCL16 elicits its effects on cells by interacting with cell surface chemokine receptors such as CCR1, CCR2, CCR5 and CCR8.

Research Category :

Angiogenesis, Cardiovascular, Chemokines, Cytokines, Immunology, Innate Immunity, Macrophage / Inflamm.

more info or order :

Boster product webpage