Human IL-1 RL1 / ST2 ELISA Kit PicoKine® | Boster EK1116 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IL-1 RL1 / ST2 ELISA Kit PicoKine®

catalog :

EK1116

quantity :

96 wells/kit, with removable strips.

price :

399 USD

more info or order :

Boster product webpage

citations: 1

Reference
Galeone A, Lessana A, Mascolo E, Di Serio F, Marraudino N, Laborde F, et al. Interleukin-1 receptor-related protein ST2 and mitral valve repair outcome in patients with chronic degenerative mitral regurgitation. Thorac Cardiovasc Surg. 2014;62:47-51 pubmed publisher

image

image 1 :

Human IL1RL1/ST2 PicoKine ELISA Kit standard curve

product information

SKU :

EK1116

Product Name :

Human IL-1 RL1 / ST2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

399 USD

Description :

Human IL-1 RL1 / ST2 ELISA Kit PicoKine® (96 Tests). Quantitate Human IL1RL1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IL1RL1

Uniprot ID :

Q01638

Immunogen :

Expression system for standard: NS0; Immunogen sequence: K19-S328

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-1 receptor-like 1

Synonyms :

Interleukin-1 receptor-like 1;Protein ST2;IL1RL1;DER4, ST2, T1;

Protein Name :

Interleukin-1 receptor-like 1

Molecular Weight :

63358 MW

Protein Function :

Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function.

Subcellular Localization :

Isoform C: Cell membrane.

Tissue Specificity :

Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle.

Sequence Similarities :

Belongs to the interleukin-1 receptor family.

Background :

Interleukin 1 receptor-like 1, also known as IL1RL1 or ST2, is a protein that in humans is encoded by the IL1RL1 gene. The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. TL1RL1 is necessary for endotoxin tolerance and, by inhibiting TLR responses, enhances Th2 responses. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

Research Category :

Angiogenesis, Cardiovascular, Cytokines, Hypertrophy, Immunology, Innate Immunity, Interleukins, Tlr Signaling

more info or order :

Boster product webpage