Human ICOS ELISA Kit PicoKine® | Boster EK1111 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ICOS ELISA Kit PicoKine®

catalog :

EK1111

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1111

Product Name :

Human ICOS ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human ICOS ELISA Kit PicoKine® (96 Tests). Quantitate Human ICOS in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 2pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ICOS

Uniprot ID :

Q9Y6W8

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E21-F141

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<2 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

inducible T-cell costimulator

Synonyms :

Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD278; ICOS; AILIM

Protein Function :

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

Subcellular Localization :

Isoform 1: Cell membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.

Background :

Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene. The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

Research Category :

Adaptive Immunity, Immunology, T Cells