Rat Cystatin C/CST3 ELISA Kit PicoKine® | Boster EK1109 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat Cystatin C/CST3 ELISA Kit PicoKine®

catalog :

EK1109

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK1109

Product Name :

Rat Cystatin C/CST3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat Cystatin C/CST3 ELISA Kit PicoKine® (96 Tests). Quantitate Rat Cst3 in cell culture supernatants, serum, plasma (heparin, EDTA) and urine. Sensitivity: 10pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

CST3

Uniprot ID :

P14841

Immunogen :

Expression system for standard: NS0; Immunogen sequence: M1-A140

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA) and urine

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cystatin-C

Synonyms :

Cystatin-C;Cystatin-3;Cst3;

Protein Name :

Cystatin-C

Molecular Weight :

15437 MW

Protein Function :

As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity. Known to inhibit cathepsin B, H, and L.

Subcellular Localization :

Secreted.

Background :

Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide), a protein encoded by the CST3 gene, was originally described as a constituent of normal cerebrospinal fluid (CSF) and of urine from patients with renal failure. Cystatin 3 has a low molecular weight (approximately 13.3 kilodaltons), and it is removed from the bloodstream by glomerular filtration in the kidneys. In mouses, all cells with a nucleus (cell core containing the DNA) produce cystatin C as a chain of 120 amino acids. It is found in virtually all tissues and bodily fluids. Cystatin C, which belongs to the type II cystatin gene family, is a potent inhibitor of lysosomal proteinases (enzymes from a special subunit of the cell that break down proteins) and probably one of the most important extracellular inhibitors of cysteine proteases (it prevents the breakdown of proteins outside the cell by a specific type of protein degrading enzymes). Moreover, cystatin C is involved in network reorganization in the epileptic dentate gyrus.

Research Category :

Apoptosis, Atherosclerosis, Cardiovascular, Caspases Etc, Cell Biology, Cell Type Markers, Intracellular, Neural Stem Cells, Stem Cells, Tags & Cell Markers, Tumor Associated