Human TNFSF14/LIGHT ELISA Kit PicoKine® | Boster EK0990 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TNFSF14/LIGHT ELISA Kit PicoKine®

catalog :

EK0990

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Celik S, Shankar V, Richter A, Hippe H, Akhavanpoor M, Bea F, et al. Proinflammatory and prothrombotic effects on human vascular endothelial cells of immune-cell-derived LIGHT. Eur J Med Res. 2009;14:147-56 pubmed

image

image 1 :

Human TNFSF14/LIGHT PicoKine ELISA Kit standard curve

product information

SKU :

EK0990

Product Name :

Human TNFSF14/LIGHT ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human TNFSF14/LIGHT ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFSF14 in cell culture supernatants, serum, plasma (heparin, EDTA) and saliva. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFSF14

Uniprot ID :

O43557

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D74-V240

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA) and saliva

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor ligand superfamily member 14

Synonyms :

Tumor necrosis factor ligand superfamily member 14;Herpes virus entry mediator ligand;HVEM-L;Herpesvirus entry mediator ligand;CD258;Tumor necrosis factor ligand superfamily member 14, membrane form;Tumor necrosis factor ligand superfamily member 14, soluble form;TNFSF14;HVEML, LIGHT;UNQ391/PRO726;

Protein Name :

Tumor necrosis factor ligand superfamily member 14

Molecular Weight :

26350 MW

Protein Function :

Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.

Subcellular Localization :

Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.

Tissue Specificity :

Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.

Background :

Tumor necrosis factor ligand superfamily member 14 is a protein that in humans is encoded by the TNFSF14 gene. TNFSF14 has also been designated as CD258, as well as LIGHT. It was mapped on chromosome 19p13.3. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.

Research Category :

Adaptive Immunity, Cytokines, Immunology, Innate Immunity, T Cells, Tnf Superfamily

more info or order :

Boster product webpage