Human TNFRSF9/4-1BB ELISA Kit PicoKine® | Boster EK0988 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TNFRSF9/4-1BB ELISA Kit PicoKine®

catalog :

EK0988

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Dongming L, Zuxun L, Liangjie X, Biao W, Ping Y. Enhanced levels of soluble and membrane-bound CD137 levels in patients with acute coronary syndromes. Clin Chim Acta. 2010;411:406-10 pubmed publisher

image

image 1 :

Human TNFRSF9/4-1BB PicoKine ELISA Kit standard curve

product information

SKU :

EK0988

Product Name :

Human TNFRSF9/4-1BB ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human TNFRSF9/4-1BB ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF9 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFRSF9

Uniprot ID :

Q07011

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L24-Q186

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 9

Synonyms :

Tumor necrosis factor receptor superfamily member 9;4-1BB ligand receptor;CDw137;T-cell antigen 4-1BB homolog;T-cell antigen ILA;CD137;TNFRSF9;CD137, ILA;

Protein Name :

Tumor necrosis factor receptor superfamily member 9

Molecular Weight :

27899 MW

Protein Function :

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Tissue Specificity :

Expressed on the surface of activated T-cells.

Sequence Similarities :

Contains 4 TNFR-Cys repeats.

Background :

CD137 is a member of the tumor necrosis factor (TNF) receptor family. Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB and induced by lymphocyte activation (ILA). CD137 gene was localized to chromosome 1p36.Members of this receptor family and their structurally related ligands are important regulators of a wide variety of physiological processes and play an especially important role in the regulation of immune responses. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.

Research Category :

Stem Cells, T Lymphocytic Lineage, Tnf Superfamily, Tumor Immunology

more info or order :

Boster product webpage